Enhancing Osteoblast Function through Resveratrol-Loaded Methoxy Poly(ethylene glycol)-Polylactic Acid Nanoparticles: A Novel Approach for Osteogenic Therapy

Abstract

The primary objective of this investigation was to assess the influence of resveratrol-loaded polymer nanoparticles (RSV-NPs) on osteoblast proliferation and differentiation, aiming to enhance the osteogenic properties of RSV and establish a practical drug delivery system for clinical bone and dental regeneration. The findings revealed that osteoblast proliferation was hindered in the RSV-NPs group, exhibiting more potent inhibition compared to the free RSV group. Both groups displayed increased ALP activity, with a notably greater rise in the RSV-NPs group than in the RSV group. Additionally, the expression of ALP, OCN, and BMP-2 mRNA was upregulated in both groups, demonstrating a more marked increase in the RSV-NPs group in comparison to the regular RSV group. In summary, the developed nanoparticles effectively improved the solubility of RSV and heightened its impact on osteoblast proliferation and differentiation. This innovative approach holds potential for targeted bone and dental tissue treatment, opening up new avenues for research in osteoporosis therapies.