Review article
Endodontics and pulp biology
Ali H. Murad; Haitham falah fadhala
Volume 1, Issue 1 , December 2023, Pages 1-11
Abstract
Root canal therapy, which involves removing the dental pulp and replacing it with a biomaterial, is the established treatment for damaged pulp. However, innovative methods promoting dental pulp regeneration could potentially restore original tooth anatomy and enhance long-term outcomes for previously ...
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Root canal therapy, which involves removing the dental pulp and replacing it with a biomaterial, is the established treatment for damaged pulp. However, innovative methods promoting dental pulp regeneration could potentially restore original tooth anatomy and enhance long-term outcomes for previously damaged teeth. This study explores the current landscape of dental pulp tissue engineering and immunomodulatory biomaterials, aiming to merge these areas for advanced therapeutic solutions. The paper reviews the inflammation and immune responses associated with dental pulp, expanding on periapical and periodontal inflammations. It highlights recent advancements in treating infection-triggered oral issues, emphasizing materials that can modulate the immune response. These developments, derived from a decade-long literature review, involve alterations to biomaterial composition and drug integrations for immunomodulation. Such advances in biomaterials leveraging the host’s immune system for targeted regeneration suggest a promising shift from traditional root canal methods to more holistic treatments.
Review article
Dental materials and biomaterials
Radwan Ali; Abdulkareem Hussain Alwan
Volume 1, Issue 1 , December 2023, Pages 12-25
Abstract
At present, titanium dioxide nanoparticles (TiO2 NPs) find effective application in human consumables, pharmaceuticals, beauty products, cutting-edge healthcare, and dental care due to their non-toxic, non-allergenic, and biocompatible properties when in direct proximity to the human body. These NPs ...
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At present, titanium dioxide nanoparticles (TiO2 NPs) find effective application in human consumables, pharmaceuticals, beauty products, cutting-edge healthcare, and dental care due to their non-toxic, non-allergenic, and biocompatible properties when in direct proximity to the human body. These NPs exhibit exceptional versatility in terms of their satisfactory chemical steadiness, cost-effectiveness, potent oxidation characteristics, elevated refractive index, and improved visual appeal. These NPs are produced using traditional techniques (both physical and chemical) as well as modern biological methods (biological, eco-friendly, and derived from biological sources), each carrying its own set of strengths and weaknesses in this current era. The importance of TiO2 NPs in the medical field encompasses applications in drug delivery, cancer treatment, orthopedic implants, biosensors, instruments, and devices. In dentistry, they play a crucial role as biomaterials in items like toothpaste, oral antibacterial solutions, teeth whitening products, and adhesives. Furthermore, TiO2 NPs hold a significant position in various dental specialties. They are utilized in orthodontics for wires and brackets, in endodontics for sealers and obturating materials, in maxillofacial surgeries for implants and bone plates, in prosthodontics for veneers, crowns, bridges, and acrylic resin dentures, and in restorative dentistry for glass ionomer cement (GIC) and composites.
Review article
Dental materials and biomaterials
Haider Nasser Jabber; Radwan Ali; Mohammed N. Al-Delfi
Volume 1, Issue 1 , December 2023, Pages 26-36
Abstract
The objective of this article is to provide a thorough examination of the evolution of dental zirconia, encompassing its varieties, characteristics, uses, and methods of cementation. A thorough exploration of PubMed and Embase databases was undertaken. The inquiry was restricted to articles published ...
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The objective of this article is to provide a thorough examination of the evolution of dental zirconia, encompassing its varieties, characteristics, uses, and methods of cementation. A thorough exploration of PubMed and Embase databases was undertaken. The inquiry was restricted to articles published in the English language. The ultimate search took place in October of 2021. Recently created monolithic Zirconia ceramics have greatly improved aesthetics and transparency. Yet, it is imperative to conduct additional in vitro and in vivo research to ascertain the material's capacity to sustain its outstanding attributes over the long term. As per the existing literature, monolithic translucent Zirconia has demonstrated encouraging outcomes and a notable rate of longevity. Therefore, this material is recommended for situations where both strength and aesthetics are required. Advancements in both the materials and techniques for cementing monolithic Zirconia have substantially improved, prompting dentists to consider using this material, particularly in situations where a conservative approach is needed. Zirconia restorations exhibited positive results, especially in the case of monolithic Zirconia crowns supported by implants and fixed dental prostheses.
Original article
Emerging technologies and therapies in dentistry
Hamed Afshari; Afnan Abdulkareem Hussain; Zaid Khalid Sehen AL-Maliki
Volume 1, Issue 1 , December 2023, Pages 37-42
Abstract
The primary objective of this investigation was to assess the influence of resveratrol-loaded polymer nanoparticles (RSV-NPs) on osteoblast proliferation and differentiation, aiming to enhance the osteogenic properties of RSV and establish a practical drug delivery system for clinical bone and dental ...
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The primary objective of this investigation was to assess the influence of resveratrol-loaded polymer nanoparticles (RSV-NPs) on osteoblast proliferation and differentiation, aiming to enhance the osteogenic properties of RSV and establish a practical drug delivery system for clinical bone and dental regeneration. The findings revealed that osteoblast proliferation was hindered in the RSV-NPs group, exhibiting more potent inhibition compared to the free RSV group. Both groups displayed increased ALP activity, with a notably greater rise in the RSV-NPs group than in the RSV group. Additionally, the expression of ALP, OCN, and BMP-2 mRNA was upregulated in both groups, demonstrating a more marked increase in the RSV-NPs group in comparison to the regular RSV group. In summary, the developed nanoparticles effectively improved the solubility of RSV and heightened its impact on osteoblast proliferation and differentiation. This innovative approach holds potential for targeted bone and dental tissue treatment, opening up new avenues for research in osteoporosis therapies.
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