Document Type : Original article


1 Department of Mechanical and Bio Mechanical Engineerig, Urmia Branch, Islamic Azad University, Urmia, Iran

2 Specialized Dental Center, Baghdad Health Directorate Ministry of Health, Baghdad 10011, Iraq.

3 Department of Medical Laboratory Technique, The Islamic university, Al Diwaniyah 58001, AL-Qadisiyah, Iraq.


The primary objective of this investigation was to assess the influence of resveratrol-loaded polymer nanoparticles (RSV-NPs) on osteoblast proliferation and differentiation, aiming to enhance the osteogenic properties of RSV and establish a practical drug delivery system for clinical bone and dental regeneration. The findings revealed that osteoblast proliferation was hindered in the RSV-NPs group, exhibiting more potent inhibition compared to the free RSV group. Both groups displayed increased ALP activity, with a notably greater rise in the RSV-NPs group than in the RSV group. Additionally, the expression of ALP, OCN, and BMP-2 mRNA was upregulated in both groups, demonstrating a more marked increase in the RSV-NPs group in comparison to the regular RSV group. In summary, the developed nanoparticles effectively improved the solubility of RSV and heightened its impact on osteoblast proliferation and differentiation. This innovative approach holds potential for targeted bone and dental tissue treatment, opening up new avenues for research in osteoporosis therapies.


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